Molecular Technologies in the Clinical Diagnostic Laboratory

Molecular Technologies in the Clinical Diagnostic Laboratory.

BACKGROUND New technologies for molecular analysis are increasing our ability to diagnose cancer. METHODS Several molecular analysis technologies are reviewed and their use in the clinical laboratory is discussed. RESULTS Select key technologies, including polymerase chain reaction and next-generation sequencing, are helping transform our ability to analyze cancer specimens. As these techno...

Introducing New Laboratory-Developed Molecular Methods in the Clinical Microbiology Laboratories

Clinical and Laboratory Findings Including the Diagnostic Value of the Widal Test in Pediatric Cases of Typhoid Fever in Tehran

Background and Objective: The diagnosis of typhoid fever in children is a challenge due to the non-specific clinical picture. The current role of the Widal test for diagnosis in developing countries has not been clear. Materials and Methods: Charts were reviewed on all children ≤ 15 years of age discharg...

I-17: Failed Fertilization: from Molecular,Diagnostic and Clinical Perspectives

Low and/or total failed fertilization following ICSI is a disappointing effect that some couples may face during their treatment which may have severe social and economic consequences for these infertile couples. This phenomenon has been mainly attributed to failed oocyte activation post ICSI. Researchers have regarded this failure due to the absence or deficiency of sperm associated to oocyte ...

Pharmacogenomics and pharmacogenetics: future role of molecular diagnostics in the clinical diagnostic laboratory.

Over the past 50 years, the clinical laboratory has evolved into a complex, technology-driven enterprise with the principal tasks of diagnosing and screening for disease, monitoring health and therapeutic response, and gauging deviations from normal physiology in humans and animals. Advances in diagnostic medicine, on the other hand, have come through the application of science and technology a...